Differential Responses to Systemic and Local Angiotensin II Infusions in Conscious Postnatal Sheep
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چکیده
منابع مشابه
Angiotensin II Type 1 Receptors and Systemic Hemodynamic and Renal Responses to Stress and Altered Blood Volume in Conscious Rabbits
We examined how systemic blockade of type 1 angiotensin (AT(1)-) receptors affects reflex control of the circulation and the kidney. In conscious rabbits, the effects of candesartan on responses of systemic and renal hemodynamics and renal excretory function to acute hypoxia, mild hemorrhage, and plasma volume expansion were tested. Candesartan reduced resting mean arterial pressure (MAP, -8 ± ...
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Fetal uninephrectomy (uni-x) at 100 days of gestation results in compensatory nephrogenesis in the remaining kidney, resulting in a 30% reduction in total nephron number in male sheep. Recently, we showed that uni-x males at 6 mo of age have elevated arterial pressure, reduced renal blood flow (RBF), glomerular filtration rate (GFR), and low plasma renin levels (Singh R, Denton K, Bertram J, Je...
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We tested the hypothesis that angiotensin II (ANG II) contributes to ventilatory and acid-base adaptations during 3-4 h of hypoxia (partial pressure of O2 in arterial blood ≈ 43 Torr) in the conscious dog. Three protocols were carried out over 3-4 h in five dogs: 1) air control, 2) 12% O2 breathing, and 3) 12% O2 breathing with ANG II receptors blocked by infusion of saralasin (0.5 μg ⋅ kg-1 ⋅ ...
متن کاملComparison of the Adrenal and Renal Responses to Angiotensin II in Fetal Lambs and Adult Sheep
The adrenal and renal responses to similar increases in plasma angiotensin II (All) were studied in chronically catheterized fetal lambs (112-131 days gestation; term 145 days) and adult nonpregnant sheep. The rate of All infusion was adjusted to compare the effect of similar rises in plasma AH concentration between fetuses and adult ewes. Increases in plasma All were associated with a decrease...
متن کاملRenal responses to hemorrhage are age dependent in conscious sheep.
Experiments were carried out in conscious, chronically instrumented lambs (n = 8) and young adult sheep (n = 11) to investigate age-dependent renal responses to hemorrhage. Various parameters of renal function were measured for 1 h before and 1 h after either 10% hemorrhage (experiment 1) or 20% hemorrhage (experiment 2). The two experiments were carried out in random order at intervals of 2-5 ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2002
ISSN: 0031-3998,1530-0447
DOI: 10.1203/01.pdr.0000030714.99576.ae